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Date back in Aristotle time, we found the establishment of the initial ground of the theory of humours. Later, Hippocrates, Jalinoos, and many others collectively supported this ancient unani concept. Immense work on humours theory reflects the importance of blood in the human body. Infact, we discovered a long time ago that diseases caused by abnormalities in humours. Therefore, this concept led to the formulation of many unani medicines for blood purification.
Ancient people were unaware of medical treatments for a long time. A large number of locals die of sudden spread of pandemic or any epidemic. Nonetheless, these were not the only death causes. Various symptoms of diseases like leukemia, anemia, and other hematological disorders had been reported but due to lack of knowledge on the subject, they had faced serious consequences. Locals and physicians of that time period used to employ hit and miss methods to solve their medical problems. But this was not applicable for blood related diseases.
Then, the ancient unani scholars took the aid of ancient unani theory of humors to have familiarity with their diseases.